Platelet-rich plasma

Platelet-rich plasma (PRP) is a drug obtained from the patient's own blood, in which the concentration of platelets is higher than in the physiological (natural) plasma. PRP was first used during cardiac surgery in 1987. Since then, significant progress has been made in manufacturing technology, and the list of diseases and defects in which platelet-rich plasma can be used has been expanded.

PRP has been the subject of many clinical trials, and attempts are also being made to standardize internationally methods for the production and administration of platelet-rich plasma in certain diseases. PRP is used not only in plastic surgery (in the treatment of chronic wounds), sports medicine and aesthetic medicine (baldness treatment, facial skin renewal procedures), but also in many other fields of medicine. Platelet-rich plasma is used in maxillofacial surgery, orthopedic surgery, and gynecological surgery. The list of dermatological indications is also expanding.

The platelet membrane has a three-layered structure consisting of a double layer of phospholipids with membrane proteins. This, in turn, is protected by a special carbohydrate layer (glycocalyx), which contains glycoproteins with the properties of receptors for factors that activate or inhibit PLT activity. It also contains plasma proteins and sialic acids, due to which the cell surface has a negative charge, preventing platelets from sticking together and sticking to other blood cells or the endothelium.

The granules and (alpha and delta) contained in platelets are surrounded by a plasma membrane. The granules contain lamellar metabolites synthesized in megakaryocytes. The membrane cavities inside the cell form a system of open channels that provide a connection between the inner part of the plate and the environment (substances released from the intraplate granules exit through the channels). In addition, platelets contain few mitochondria and peroxisomes, vesicular structures (microbody) with oxidizing enzymes that can oxidize various compounds, such as reactive oxygen species (free radicals). Platelets, due to peroxisomes, can slow down the processes of cellular aging.

As already mentioned, platelets are the main element in the processes of hemostasis and blood clots formation. They are involved in sealing and ensuring the integrity of the vascular wall. In case of damage to the vascular endothelium, platelets bind to the von Willebrand factor and attach to collagen and other vascular wall proteins. They are stimulated, and the products synthesized in the granules are released after activation. Watch USA online porn https://mat6tube.com teens, milfs, matures!